ABOUT ME
I studied for a PhD in developmental biology at the Univeristy of Edinburgh in the MRC Reproductive Biology Unit. After completing my PhD I moved to Leeds and worked as a PDRA in Prof Margaret Knowles's lab studying the function of growth factor receptors in bladder cancer. In 2010 I set up two facilities in Leeds - a siRNA screening facility and a facility to produce non-antibody binding proteins. In 2015 I became a University Academic Fellow at Leeds to build a research group to fully exploit the use of Affimers for studying protein function. In 2018 I was promoted to Associate Professor.
Selected Current Funding
RESEARCH INTERESTS
Protein Engineering
Further development of the scaffold protein, libraries and engineering binders to increase affinity
2016 -
Medical Research Council £3,800,000
Part of a large group at Leeds funded to accelerate the development of infection diagnostics.
Studying signalling cascades in cancer
Developing Affimers to block protein-protein interactions in cells
Inhibition of membrane proteins
Block receptor function using Affimer reagents
Anti-bacterial reagents
Developing Affimers that can be used as anti bacterials in combination with antibiotics
2019 -
EPSRC - £1,660,000
Photonic Sensing and Dual-mode Bio-Imaging with Rare Earth Upconversion Nanoparticles with Gin Jose.
2018 -
BHF - £270,000
Attenuating cardiac inflammation and remodelling by targeting the Tenascin C - TLR4 axis with Azhar Maqbool
2018 -
BBSRC- £617,000
Exploiting the power of heterologous expression in plants to discover new virus with Neil Ranson