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ABOUT ME

I studied for a PhD in developmental biology at the Univeristy of Edinburgh in the MRC Reproductive Biology Unit. After completing my PhD I moved to Leeds and worked as a PDRA in Prof Margaret Knowles's lab studying the function of growth factor receptors in bladder cancer. In 2010 I set up two facilities in Leeds - a siRNA screening facility and a facility to produce non-antibody binding proteins. In 2015 I became a University Academic Fellow at Leeds to build a research group to fully exploit the use of Affimers for studying protein function. In 2018 I was promoted to Associate Professor.

Selected Current Funding

RESEARCH INTERESTS

Protein Engineering

Further development of the scaffold protein, libraries and engineering binders to increase affinity

2016 -

Medical Research Council £3,800,000

Part of a large group at Leeds funded to accelerate the development of infection diagnostics.

Studying signalling cascades in cancer

Developing Affimers to block protein-protein interactions in cells

Inhibition of membrane proteins

Block receptor function using Affimer reagents

Anti-bacterial reagents

Developing Affimers that can be used as anti bacterials in combination with antibiotics

2019 -

EPSRC - £1,660,000

Photonic Sensing and Dual-mode Bio-Imaging with Rare Earth Upconversion Nanoparticles with Gin Jose.

2018 -

BHF - £270,000

Attenuating cardiac inflammation and remodelling by targeting the Tenascin C - TLR4 axis with Azhar Maqbool

2018 -

BBSRC- £617,000

Exploiting the power of heterologous expression in plants to discover new virus with Neil Ranson

2019 -

BBSRC - £775,000

Understanding how proteins are organised in the Z-disk, a super-resolution approach with Michelle Peckham.

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